15 Activated platelets secrete angiogenic growth factors, which contribute to tumor angiogenesis and thereby promote tumor formation. Platelets have been suggested to play an important role in the progression and metastasis of cancer. Several clinical studies have investigated the association between platelet counts and survival times in cancer patients. Further prospective studies with a larger number of patients in high-volume endocrine surgery centers are required to confirm our findings. We propose that MPV might be an important predictive factor for thyroid malignancies. MPV was significantly higher in patients with thyroid malignancies than in patients with benign thyroid diseases. Age, sex, hemoglobin level, WBC count, and platelet count did not significantly differ between the 2 groups. MPV was significantly higher in patients with malignant thyroid diseases than in those with benign thyroid diseases. Data on age, sex, MPV, white blood cell (WBC) count, hemoglobin level, and platelet count were collected retrospectively. This study involved 146 patients who underwent total thyroidectomy because of benign (99 patients) or malignant (47 patients) diseases of the thyroid. Therefore, in conditions that involve increased platelet activation, an increase in the proportion of young platelets and MPV is expected. Large platelets are relatively new, more reactive, and produce more thrombogenic factors. Platelets differ in terms of functional activity and size. MPV is a useful early indicator of platelet activation. If these treatments are not able to control ITP, the health care provider may recommend, splenectomy, which is the surgical removal of the spleen.This study aimed to determine the relationship between mean platelet volume (MPV) and thyroid malignancy by comparing patients who underwent surgery for benign or malignant thyroid diseases. However, if platelet counts get very low or bleeding is significant, your health care provider may begin immediate treatment with corticosteroids, intravenous immunoglobulin or anti-D immunoglobulin (both of which affect the immune system and how it interacts with platelets), or immunosuppressive drugs that make the immune system less likely to attack. In mild cases of ITP, no treatment may be needed other than careful observation by a health care provider.
The symptoms include small or medium sized spots (petechiae and purpura) showing where bleeding has happened.
ITP is a condition in which the immune system attacks the platelets. The most common child and adolescent platelet disorder is immune thrombocytopenia (ITP, also called idiopathic thrombocytopenia). Bleeding may happen in other parts of the body, such as mucous membranes, gums, nose bleeds, and the gastrointestinal tract.
#HIGH MPV NORMAL PLATELET COUNT SKIN#
Platelet bleeding is defined by bleeding into the skin which causes a purplish stain referred to by its size: petechiae (small red or purple dots on the skin), purpura (mediam-sized spots on the skin), ecchymoses (larger areas of discoloration or bruising). Abnormal platelet function can sometimes exist from birth, but is frequently caused by medication such as aspirin and anti-inflammatory drugs.
Platelets are a part of the blood whose main job is to stop bleeding by clumping together and plugging up injuries to blood vessels, such as from a cut.
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